文献No. |
対象サンプル |
引用(リンク) |
1 |
A2780(ヒト卵巣癌) |
Caroline J. Breitbach et al., " Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans " Nature, 2011, 477(7362), 99-102. |
2 |
A549(ヒト肺癌) |
K. Hattori et al., " Cold stress‐induced ferroptosis involves the ASK1‐p38 pathway " EMBO Rep., 2017, 18, 2067-2078, doi: 10.15252/embr.201744228. |
3 |
A549(ヒト肺癌) |
T. Ida et al., " Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling " Proc. Natl. Acad. Sci., 2014, 111(21), 7606 |
4 |
A549(ヒト肺癌、4%PFA固定) |
R. Tanino et al., " Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer " Oncotarget., 2018, 9(24), 16807–16821, doi: 10.18632/oncotarget.24704. |
5 |
AGS(ヒト胃腺癌) |
Y. Hayakawa et al., " Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer " Proc. Natl. Acad. Sci., 2011, 108(2), 780 |
6 |
ALL(Human acute lymphoid leukemia) |
Zhengshan Chen et al., " Signaling thresholds and negative B-cell selection in acute lymphoblastic leukaemia " Nature, 2015, 521, 357–361. |
7 |
Ba/F3(マウスpro-B細胞) |
Marcin Imielinski et al., " Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing " Cell, 2012, 150(6), 1107-1120. |
8 |
BALB/3T3(マウス線維芽細胞) |
H. Tominaga et al., " A water-soluble tetrazolium salt useful for colorimetric cell viability assay " Anal. Commun., 1999, 36, 47 |
9 |
C3H10T1/2(マウス胚) |
S. F. Jin et al., " XL413, a cell division cycle 7 kinase inhibitor enhanced the anti-fibrotic effect of pirfenidone on TGF-β1-stimulated C3H10T1/2 cells via Smad2/4. " Exp Cell Res., 2015, 339(2), 289-99, doi: 10.1016/j.yexcr.2015.11.013. |
10 |
dermal fibroblasts(ヒト皮膚線維芽細胞) |
Thomas Wohlfahrt et al., " PU.1 controls fibroblast polarization and tissue fibrosis " Nature, 2019, 566, 344–349. |
11 |
EA.Hy926(ヒト血管内皮細胞) |
Y. Xu et al., " Survivin regulated by autophagy mediates hyperglycemia-induced vascular endothelial cell dysfunction " Exp. Cell Res., 2018, 364(2), 152-159, doi: 10.1016/j.yexcr.2018.01.037. |
12 |
Endothelial cell(内皮細胞) |
Virginia Guarani et al., " Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase " Nature, 2011, 473(7346), 234-238. |
13 |
FaDu(ヒト咽頭癌) |
Hiba Ahmad Zahreddine et al., " The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation " Nature, 2014, 511(7507), 90-93. |
14 |
glioblastoma cells(ヒト神経膠芽腫) |
Wan Li et al., " 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase " J Exp Clin Cancer Res. , 2018, 37(1), 132, doi: 10.1186/s13046-018-0805-4. |
15 |
HCC(肝細胞癌) |
Kun Chen et al., " Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity " Cell, 2017, 170(3), 492-506. |
16 |
HCE(ヒト角膜上皮) |
Y. Huo et al., " The protective effect of EGF-activated ROS in human corneal epithelial cells by inducing mitochondrial autophagy via activation TRPM2. " J Cell Physiol., 2020, doi: 10.1002/jcp.29597., |
17 |
HCT116(ヒト結腸腺癌) |
TaChung Yu et al., " Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy " Cell, 2017, 170(3), 548-563. |
18 |
HDF38(線維芽細胞) |
Y. Takeda et al., " A developed serum-free medium and an optimized chemical cocktail for direct conversion of human dermal fibroblasts into brown adipocytes " 2020, 10, 3775. doi: 10.1038/s41598-020-60769-x., |
19 |
HEK293(ヒト胎児腎細胞、SFXN2ノックアウト) |
E. E. Mon et al., " Regulation of mitochondrial iron homeostasis by siderofexin 2 " J Physiol Sci., 2019, 69(2), 359-373, doi: 10.1007/s12576-018-0652-2. |
20 |
HEK293T(ヒト胎児腎細胞) |
Liqiang Pan et al., " Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling " Cell, 2019, 176(6), 1477-1489. |
21 |
HeLa(ヒト子宮頸癌) |
Christian Münch et al., " Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation " Nature, 2016, 534, 710-713. |
22 |
HeLa(ヒト子宮頸癌) |
M. Ishiyama et al., " A Highly Water-Soluble Disulfonated Tetrazolium Salt as a Chromogenic Indicator for NADH as Well as Cell Viability " Talanta., 1997, 44, 1299 |
23 |
HeLa(ヒト子宮頸癌) |
H. Tominaga et al., " A water-soluble tetrazolium salt useful for colorimetric cell viability assay " Anal. Commun., 1999, 36, 47 |
24 |
hepatocytes(肝細胞) |
H. Nakagawa et al., " ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development " Cancer Cell, 2014, 26(3), 331-343, doi: 10.1016/j.ccr.2014.07.001. |
25 |
HepG2(ヒト肝臓癌) |
Melissa L. Hancock et al., " Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression " Cell, 2019, 177(3), 722-736. |
26 |
HepG2(ヒト肝臓癌) |
L. Hu et al., " Notoamide-type alkaloid induced apoptosis and autophagy via a P38/JNK signaling pathway in hepatocellular carcinoma cells " RSC Adv., 2019, 9, 19855-19868. |
27 |
HL60(ヒト白血病) |
H. Tominaga et al., " A water-soluble tetrazolium salt useful for colorimetric cell viability assay " Anal. Commun., 1999, 36, 47 |
28 |
HLMVEC(ヒト肺微小血管内皮細胞) |
K. Koike et al., " Role of Glucosylceramide in Lung Endothelial Cell Fate and Emphysema " Am J Respir Crit Care Med., 2019, 200(9), 1113-1125, doi: 10.1164/rccm.201812-2311OC. |
29 |
HRCEpiC(ヒト腎皮質上皮細胞) |
Y. Zhao et al., " Metformin rescues Parkin protein expression and mitophagy in high glucose-challenged human renal epithelial cells by inhibiting NF-κB via PP2A activation. " Life Sci., 2020, 246, 117382, doi: 10.1016/j.lfs.2020.117382. |
30 |
HRPTEpic(ヒト腎近位尿細管上皮細胞) |
Y. Zhao et al., " Metformin rescues Parkin protein expression and mitophagy in high glucose-challenged human renal epithelial cells by inhibiting NF-κB via PP2A activation. " Life Sci., 2020, 246, 117382, doi: 10.1016/j.lfs.2020.117382. |
31 |
HT29(ヒト結腸腺癌) |
TaChung Yu et al., " Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy " Cell, 2017, 170(3), 548-563. |
32 |
HT29(ヒト結腸腺癌) |
Yonghyun Lee et al., " Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis " Nature Materials, 2019, doi: 10.1038/s41563-019-0462-9, |
33 |
Huh-7(ヒト肝細胞癌) |
L. Hu et al., " Notoamide-type alkaloid induced apoptosis and autophagy via a P38/JNK signaling pathway in hepatocellular carcinoma cells " RSC Adv., 2019, 9, 19855-19868. |
34 |
HUVEC(ヒト臍帯静脈内皮細胞) |
N. Li et al., " MoS2-LA-PEI nanocomposite carrier for real-time imaging of ATP metabolism in glioma stem cells co-cultured with endothelial cells on a microfluidic system " Biosens Bioelectron., 2017, 99(2018), 142 |
35 |
HUVEC(ヒト臍帯静脈内皮細胞) |
T. Tu et al., " CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development " Cell Res., 2015, 25(3), 275 |
36 |
KM-H2(ホジキン病細胞) |
Motohiro Kato et al., " Frequent inactivation of A20 in B-cell lymphomas " Nature, 2009, 459(7247), 712-716 . |
37 |
L02(ヒト肝細胞) |
Qingqiang Xu et al., " Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy " Cell Death Dis., 2020, 11(1), 6, doi: 10.1038/s41419-019-2197-6. |
38 |
L02(ヒト肝細胞) |
D. Zhou et al., " Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line. " PLoS One., 2016, 11(10), e0165224, doi: 10.1371/journal.pone. |
39 |
L929(マウス結合組織) |
H. Tominaga et al., " A water-soluble tetrazolium salt useful for colorimetric cell viability assay " Anal. Commun., 1999, 36, 47 |
40 |
LAN-2(神経芽細胞腫) |
Yuyan Chen et al., " Oncogenic mutations of ALK kinase in neuroblastoma " Nature, 2008, 455(7215), 971-974. |
41 |
Leukemia cells(ヒト白血病) |
Gang Xiao et al., " B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies " Cell., 2018, 173(2), 470-484. |
42 |
MC3T3-E1(マウス頭蓋冠) |
A. Oyane et al., " Laser-assisted wet coating of calcium phosphate for surface-functionalization of PEEK " PLoS One., 2018, 13(10), doi: 10.1371/journal.pone.0206524. |
43 |
MCF7(ヒト乳癌) |
K. Takayam et al., " Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes " Proc. Natl. Acad. Sci., 2014, 111(47), 16772 |
44 |
MEF(マウス胎児線維芽細胞) |
Daniel Cortázar et al., " Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability " Nature, 2011, 470(7334), 419-423. |
45 |
MEF(マウス胎児線維芽細胞) |
Y. Takanezawa et al., " Atg5-dependent autophagy plays a protective role against methylmercury-induced cytotoxicity " Toxicol. Lett., 2016, 262, 135-141, doi: 10.1016/j.toxlet.2016.09.007. |
46 |
MIA PaCa-2(ヒト膵臓癌) |
R. Chugh et al., " A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer " Sci. Transl. Med., 2012, 4(156), 156ra139, doi: 10.1126/scitranslmed.3004334. |
47 |
MKN45(ヒト腺癌) |
Y. Hayakawa et al., " Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer " Proc. Natl. Acad. Sci., 2011, 108(2), 780 |
48 |
MKN74(ヒト管状腺癌) |
Y. Hayakawa et al., " Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer " Proc. Natl. Acad. Sci., 2011, 108(2), 780 |
49 |
Neurons(神経細胞) |
Kazuhide Hayakawa et al., " Transfer of mitochondria from astrocytes to neurons after stroke " Nature, 2016, 535, 551-555. |
50 |
Osteoblasts(骨芽細胞) |
Toru Fukuda et al., " Sema3A regulates bone-mass accrual through sensory innervations " Nature, 2013, 497(7450), 490-493. |
51 |
Panc02(マウス膵臓癌) |
R. Kang et al., " The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia " Proc. Natl. Acad. Sci., 2012, 109(18), 7031 |
52 |
Panc-1(ヒト膵臓腺癌) |
R. Chugh et al., " A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer " Sci. Transl. Med., 2012, 4(156), 156ra139, doi: 10.1126/scitranslmed.3004334. |
53 |
PHH(primary human hepatocytes) |
K. Takayam et al., " Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes " Proc. Natl. Acad. Sci., 2014, 111(47), 16772 |
54 |
PHH-iPS-HLCs(primary human hepatocytes–human induced pluripotent stem cells–hepatocyte-like cells) |
K. Takayam et al., " Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes " Proc. Natl. Acad. Sci., 2014, 111(47), 16772 |
55 |
primary neuron(Mouse) |
James A. Duce et al., " Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease " Cell, 2010, 142(6), 857-867. |
56 |
RAW264.7(マウスマクロファージ細胞) |
Zhen-Shun Gan et al., " Iron Reduces M1 Macrophage Polarization in RAW264.7 Macrophages Associated with Inhibition of STAT1 " Hindawi, 2017, doi: 10.1155/2017/8570818, |
57 |
RC(rabbit cornea) |
H. Tominaga et al., " A water-soluble tetrazolium salt useful for colorimetric cell viability assay " Anal. Commun., 1999, 36, 47 |
58 |
RBL-2H3(ラット白血病) |
Ha-Kyoung Kwon et al., " Phellinus linteus Grown on Germinated Brown Rice Inhibits IgE-Mediated Allergic Activity through the Suppression of FcεRI-Dependent Signaling Pathway In Vitro and In Vivo " Hindawi, 2019, doi: 10.1155/2019/1485015., |
59 |
RT2(ラット) |
Anjana Jain et al., " Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres " Nature Materials, 2014, 13(3), 308-16. |
60 |
S2-013(ヒト膵臓癌) |
R. Chugh et al., " A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer " Sci. Transl. Med., 2012, 4(156), 156ra139, doi: 10.1126/scitranslmed.3004334. |
61 |
S2-VP10(ヒト膵臓癌) |
R. Chugh et al., " A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer " Sci. Transl. Med., 2012, 4(156), 156ra139, doi: 10.1126/scitranslmed.3004334. |
62 |
SH-SY5Y(ヒト神経芽細胞種) |
R. Watanabe et al., " Protective Effects of Fisetin Against 6-OHDA-Induced Apoptosis by Activation of PI3K-Akt Signaling in Human Neuroblastoma SH-SY5Y Cells. " Neurochem. Res., 2018, 43(2), 488-499. |
63 |
SK-N-SH(ヒト神経芽細胞腫) |
Yuyan Chen et al., " Oncogenic mutations of ALK kinase in neuroblastoma " Nature, 2008, 455(7215), 971-974. |
64 |
Splenic lymphocytes(脾臓リンパ球) |
T. Miyamoto et al., " Lymphocyte Proliferation Response During Eimeria tenella Infection Assessed by a New, Reliable, Nonradioactive Colorimetric Assay " Avian Dis., 2002, 46, 10 |
65 |
SW1990(ヒト膵癌) |
S. Ji et al., " ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer " Cell Res., 2015, 25(5), 561 |
66 |
T-47D(ヒト乳腺癌) |
K. Takayam et al., " Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes " Proc. Natl. Acad. Sci., 2014, 111(47), 16772 |
67 |
TMK1(ヒト胃癌) |
Y. Hayakawa et al., " Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer " Proc. Natl. Acad. Sci., 2011, 108(2), 780 |
68 |
U251(ヒトグリア芽腫) |
Wan Li et al., " 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase " J Exp Clin Cancer Res. , 2018, 37(1), 132, doi: 10.1186/s13046-018-0805-4. |
69 |
U87(ヒト神経膠芽腫) |
N. Li et al., " MoS2-LA-PEI nanocomposite carrier for real-time imaging of ATP metabolism in glioma stem cells co-cultured with endothelial cells on a microfluidic system " Biosens Bioelectron., 2017, 99(2018), 142 |
70 |
U87 MG(ヒト神経膠芽腫) |
Anjana Jain et al., " Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres " Nature Materials, 2014, 13(3), 308-16. |
71 |
U87 MG(ヒト神経膠芽腫) |
Wan Li et al., " 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase " J Exp Clin Cancer Res. , 2018, 37(1), 132, doi: 10.1186/s13046-018-0805-4. |
72 |
Vero(アフリカミドリザル腎臓上皮細胞) |
K. Yoshimura et al., " Shiga toxin 1 and 2 Induce Apoptosis in the Amniotic cell line WISH " J. Soc. Gynecol. Investig., 2002, 9, 22 |
73 |
WISH(ヒト羊膜) |
K. Yoshimura et al., " Shiga toxin 1 and 2 Induce Apoptosis in the Amniotic cell line WISH " J. Soc. Gynecol. Investig., 2002, 9, 22 |